Resveratrol

Naturally present in grape skins, blueberries and Japanese knotweed, resveratrol activates sirtuin proteins — particularly SIRT1 — and is one of the most extensively studied polyphenols in longevity research. The "French Paradox" hypothesis (low cardiovascular disease in France despite a high-fat diet) drew global attention to this molecule.

Mechanism

Resveratrol activates SIRT1 and effectively "mimics caloric restriction." Caloric restriction is the most robustly documented intervention extending lifespan in many model organisms, and a substantial part of its effect operates through the SIRT1/NAD+ axis. By activating this pathway, resveratrol produces a similar signalling environment: mitochondrial biogenesis increases, inflammatory NF-κB signalling is suppressed, oxidative stress declines and autophagy strengthens.

Clinical data suggest AMPK activation, improved insulin sensitivity, reduced LDL oxidation and lower platelet aggregation — supporting cardiometabolic health.

Clinical Highlights

Human studies show favourable effects on blood pressure, endothelial function and insulin sensitivity. Effects on muscle function and mitochondrial capacity in elderly and diabetic patients are under investigation; resveratrol may also reduce inflammatory markers linked to neurodegeneration.

The Bioavailability Problem and Solutions

Standard oral resveratrol has poor bioavailability; it is rapidly metabolised to glucuronide and sulphate conjugates. Liposomal encapsulation, micronised powder formulations and combinations with piperine (black-pepper extract) are the main strategies to improve absorption. IV-based longevity formulations also address this issue.

Personalised Protocol

Resveratrol works best in combination with NAD+ precursors (NMN, NR), curcumin, quercetin and omega-3 — producing synergistic longevity effects. Dose, form and combinations are planned individually.