NAD+ (nicotinamide adenine dinucleotide) is a coenzyme central to cellular energy production, DNA repair and sirtuin signalling. Tissue levels decline markedly with age. Restoring NAD+ through intravenous administration is one of the most studied modalities in longevity medicine.
What Does NAD+ Do?
NAD+ is required by every mitochondrion to convert nutrients into ATP, the cell's energy currency. It also activates sirtuins — a family of "longevity genes" that regulate inflammation, mitochondrial biogenesis and chromatin stability — and supplies the substrate for PARP enzymes that repair damaged DNA. As intracellular NAD+ falls with age, all of these processes slow down: energy drops, repair backlog accumulates, and inflammatory tone rises.
Indications
NAD+ infusions are used in longevity protocols for chronic fatigue, brain fog, mitochondrial dysfunction, post-viral recovery, jet lag and as a general "biological reset". They are not curative for disease but support cellular function as part of a comprehensive plan.
How a Session Works
NAD+ is delivered as a slow intravenous infusion lasting 2–4 hours. The slow rate is important — rapid infusion may cause chest tightness or flushing. Doses typically range from 250 mg to 1000 mg per session depending on goal and prior exposure. Most longevity protocols use 5–10 sessions over a few weeks, then a monthly maintenance dose.
Combinations
NAD+ is often combined with glutathione, methylated B-vitamins (especially B3, B6, B12 and methylfolate), magnesium and high-dose vitamin C in a single integrated longevity protocol. Hormone optimisation, exercise and dietary changes further amplify the benefit.
Safety
NAD+ is a naturally occurring molecule and has a strong safety profile when administered by experienced clinicians at appropriate doses and infusion rates. Mild side effects during infusion (flushing, chest tightness, nausea) are dose-rate-related and resolve by slowing the infusion. Pregnancy, breastfeeding and active malignancy are general contraindications for IV longevity protocols.
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